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<p class="page-header"><strong><span style="font-size: 24px;">[spacer height="7px"]Dosing Amounts</span></strong></p>


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<strong><span style="font-size: 20px;">Daily Amounts Fact Sheet ~ Health Canada</span></strong>

When considering the use of cannabis for medical purposes, it is understandable that patients and healthcare practitioners may have questions regarding dosage and daily amounts of cannabis for specific medical conditions. The following information has been prepared to provide patients and healthcare practitioners with information related to daily amounts and dosing. The information provided in this fact sheet should be used in combination with the Consumer Information Insert that accompanies each shipment of marijuana for medical purposes.

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<h2><span style="font-size: 20px;">Onset, Peak, and Duration of Effects</span></h2>
With inhalation (smoking, vaporizing), effects may be felt within a few minutes of dosing and will generally peak within 30 mins.<sup><a id="fnb1-ref" class="footnote-link" href="http://www.hc-sc.gc.ca/dhp-mps/marihuana/med/daily-quotidienne-eng.php#fnb1" target="_blank"><span class="cn-invisible">Footnote </span>1</a></sup> Acute effects generally last between 2 and 4 hours but may be longer (e.g. 24 hours).<sup><a id="fnb2-ref" class="footnote-link" href="http://www.hc-sc.gc.ca/dhp-mps/marihuana/med/daily-quotidienne-eng.php#fnb2" target="_blank"><span class="cn-invisible">Footnote </span>2</a></sup>

With oral ingestion (e.g. oils, foods, capsules), acute effects may begin to be felt as quickly as 30 mins and as late as 3 or 4 hours after administration.<sup><a id="fnb3-ref" class="footnote-link" href="http://www.hc-sc.gc.ca/dhp-mps/marihuana/med/daily-quotidienne-eng.php#fnb3" target="_blank"><span class="cn-invisible">Footnote </span>3</a></sup> This variability in timing depends on a number of factors (e.g. amount of food in stomach). It is prudent to wait a minimum of 2 hours between administration of single doses of oral products to avoid possible overdosing.<sup><a id="fnb4-ref" class="footnote-link" href="http://www.hc-sc.gc.ca/dhp-mps/marihuana/med/daily-quotidienne-eng.php#fnb4" target="_blank"><span class="cn-invisible">Footnote </span>4</a></sup> Acute effects generally peak between 3 and 4 hours after dosing and can last up to 8 hours or longer e.g. 12–24 hours).<sup><a id="fnb5-ref" class="footnote-link" href="http://www.hc-sc.gc.ca/dhp-mps/marihuana/med/daily-quotidienne-eng.php#fnb5" target="_blank"><span class="cn-invisible">Footnote </span>5</a></sup>

With topical application, it is not known how long it takes for potential therapeutic effects to appear, nor how long they last. There have been reports of hypersensitivity reactions (e.g. rashes, itching) when skin has come into contact with cannabis.<sup><a id="fnb6-ref" class="footnote-link" href="http://www.hc-sc.gc.ca/dhp-mps/marihuana/med/daily-quotidienne-eng.php#fnb6" target="_blank"><span class="cn-invisible">Footnote </span>6</a></sup>

<strong><span style="font-size: 20px;">Dosing Amounts</span></strong>

Information obtained from a limited number of small and short-term clinical studies of cannabis for medical purposes indicate the daily doses of smoked or vapourized dried cannabis ranged from as little as 75 mg of dried cannabis 9.4% THC by weight) (i.e. 7 mg THC/day) to a maximum of 3.2 grams of dried cannabis (1–8% THC by weight; i.e. 32 to 256 mg THC).<sup><a id="fnb7-ref" class="footnote-link" href="http://www.hc-sc.gc.ca/dhp-mps/marihuana/med/daily-quotidienne-eng.php#fnb7" target="_blank"><span class="cn-invisible">Footnote </span>7</a></sup>,<sup><a id="fnb8-ref" class="footnote-link" href="http://www.hc-sc.gc.ca/dhp-mps/marihuana/med/daily-quotidienne-eng.php#fnb8" target="_blank"><span class="cn-invisible">Footnote </span>8</a></sup>

Doses of THC as low as 2.5–3 mg of THC (and even lower) are associated with a therapeutic benefit and minimal psychoactivity. <sup><a id="fnb9-ref" class="footnote-link" href="http://www.hc-sc.gc.ca/dhp-mps/marihuana/med/daily-quotidienne-eng.php#fnb9"><span class="cn-invisible">Footnote </span>9</a></sup>,<sup><a id="fnb10-ref" class="footnote-link" href="http://www.hc-sc.gc.ca/dhp-mps/marihuana/med/daily-quotidienne-eng.php#fnb10" target="_blank"><span class="cn-invisible">Footnote </span>10</a></sup>,<sup><a id="fnb11-ref" class="footnote-link" href="http://www.hc-sc.gc.ca/dhp-mps/marihuana/med/daily-quotidienne-eng.php#fnb11" target="_blank"><span class="cn-invisible">Footnote </span>11</a></sup>

Various surveys published in the peer-reviewed scientific and medical literature have suggested that the majority of people using smoked <strong>or</strong> orally ingested cannabis for medical purposes reported using between 10–20 grams of cannabis per week, or approximately 1–3 grams of dried cannabis per day. <sup><a id="fnb12-ref" class="footnote-link" href="http://www.hc-sc.gc.ca/dhp-mps/marihuana/med/daily-quotidienne-eng.php#fnb12" target="_blank"><span class="cn-invisible">Footnote </span>12</a></sup>

One study reported the average daily dose of dried cannabis (of various potencies) used by patients in the Netherlands’ Medical Cannabis program was 0.68 grams per day (range: 0.65 –0.82 grams per day).<sup><a id="fnb13-ref" class="footnote-link" href="http://www.hc-sc.gc.ca/dhp-mps/marihuana/med/daily-quotidienne-eng.php#fnb13" target="_blank"><span class="cn-invisible">Footnote </span>13</a></sup>

Another study suggests that regardless of route of administration (inhalation vs. oral), individuals reporting use of cannabis for medical purposes reported consuming equivalent amounts of cannabis per day and that amount averaged at around 3 grams per day. <sup><a id="fnb14-ref" class="footnote-link" href="http://www.hc-sc.gc.ca/dhp-mps/marihuana/med/daily-quotidienne-eng.php#fnb14" target="_blank"><span class="cn-invisible">Footnote </span>14</a></sup>
<ul>
 	<li>For smoking and vapourizing, the median reported dose was 1.5–2.0 grams per day respectively.</li>
 	<li>For edibles, the median reported dose was 1.5 grams per day.</li>
 	<li>For teas, the median reported dose was 1.5 grams per day.</li>
</ul>
There is no information available on dosing amounts for topically applied cannabis products (e.g. ointments, creams, lotions, oils, balms, salves), however one study suggests approximately 5% of individuals who use marijuana for medical purposes use such products.<sup><a id="fnb15-ref" class="footnote-link" href="http://www.hc-sc.gc.ca/dhp-mps/marihuana/med/daily-quotidienne-eng.php#fnb15" target="_blank"><span class="cn-invisible">Footnote </span>15</a></sup>

There is no information available on dosing amounts for fresh marijuana.

In the absence of any clinical studies conducted with cannabis products, such as oils that are ingested orally, the following information has been provided as a reference to give some potential guidance around dosing.

For products such as oils that are ingested orally
<ul>
 	<li>The available clinical evidence for Marinol<sup>®</sup>, an orally administered capsule that has received market authorization and that contains synthetic THC dissolved in sesame oil, indicates a dosing range from as low as 2.5 mg THC per day to a maximum dose of 210 mg THC per day.<sup><a id="fnb16-ref" class="footnote-link" href="http://www.hc-sc.gc.ca/dhp-mps/marihuana/med/daily-quotidienne-eng.php#fnb16" target="_blank"><span class="cn-invisible">Footnote </span>16</a></sup>,<sup><a id="fnb17-ref" class="footnote-link" href="http://www.hc-sc.gc.ca/dhp-mps/marihuana/med/daily-quotidienne-eng.php#fnb17" target="_blank"><span class="cn-invisible">Footnote </span>17</a></sup>,<sup><a id="fnb18-ref" class="footnote-link" href="http://www.hc-sc.gc.ca/dhp-mps/marihuana/med/daily-quotidienne-eng.php#fnb18" target="_blank"><span class="cn-invisible">Footnote </span>18</a></sup> Doses lower than 2.5 mg (e.g. 1 mg) THC may further avoid incidence and risks of adverse effects.</li>
 	<li>Average dose of Marinol<sup>®</sup> is 20 mg THC per day.<sup><a id="fnb19-ref" class="footnote-link" href="http://www.hc-sc.gc.ca/dhp-mps/marihuana/med/daily-quotidienne-eng.php#fnb19" target="_blank"><span class="cn-invisible">Footnote </span>19</a></sup></li>
 	<li>Maximal recommended daily oral dose of Marinol<sup>®</sup> is 40 mg per day.<sup><a id="fnb20-ref" class="footnote-link" href="http://www.hc-sc.gc.ca/dhp-mps/marihuana/med/daily-quotidienne-eng.php#fnb20" target="_blank"><span class="cn-invisible">Footnote </span>20</a></sup>, <sup><a id="fnb21-ref" class="footnote-link" href="http://www.hc-sc.gc.ca/dhp-mps/marihuana/med/daily-quotidienne-eng.php#fnb21" target="_blank"><span class="cn-invisible">Footnote </span>21</a></sup></li>
 	<li>Preliminary information from an open-label clinical trial with Epidiolex<sup>®</sup> (an orally administered oil extract containing mainly cannabidiol (CBD) for treatment of certain types of childhood epilepsy not responsive to conventional treatment), suggests a daily dosing range between 5 and 20 mg/kg CBD.<sup><a id="fnb22-ref" class="footnote-link" href="http://www.hc-sc.gc.ca/dhp-mps/marihuana/med/daily-quotidienne-eng.php#fnb22" target="_blank"><span class="cn-invisible">Footnote </span>22</a></sup> However, further clinical studies are required to substantiate this information.</li>
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[spacer height="10px"]The information above can be found on the <a href="http://www.hc-sc.gc.ca/dhp-mps/marihuana/med/daily-quotidienne-eng.php" target="_blank">Health Canada</a> website.

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* The material here is provided for educational and informational purposes only, and is not intended to be a substitute for a health care provider’s consultation. Please consult your own appropriate health care provider about the applicability of any opinions or recommendations with respect to your own symptoms or medical conditions. The information herein does not constitute health, legal or technical advice.

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